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Research Report A leading global R&D planning and evaluation institute for technological innovation in food, agriculture and forestry

LAST UPDATE : 2016-01-01

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Subject Development of allogeneic NK cell-based immunotherapy.....
Date 2016-12-15 18:08:18 Hit 307
Data
Contents Title : Development of allogeneic NK cell-based immunotherapy against cancers in dogs


Natural killer (NK) cells are lymphocytes of the innate immune system that are
responsible for eradication of cancer cells and virus-infected cells. Adoptive transfer
of NK cells to cancer patients is an attractive therapeutic approach, because NK cells
have powerful anti-tumor activity without the side effect of graft versus host disease
(GVHD). One of the major issues in the development of NK cell therapy is the low
numbers of NK cells that can be obtained from donor blood, since successful NK cell
immunotherapies require an adequate number of NK cells with strong effector function.
In this study, we developed the techniques for large scale ex vivo expansion of canine
NK cells to facilitate adoptive transfer for cancer immunotherapy. We also established
the cryopreservation technique using a new xeno-free cryopreserve-media containing
DMSO and anhydrous dextrose, and the method for restoration activity of
cryopreserved expanded NK cells after thawing. The chimera assay for immune
monitoring is developed to confirm the safety and anticancer effect of allogeneic NK
cells after infusion. The results of this study strongly suggest that the aAdoptive
transfer of allogeneic NK cells to cancer patients in the context of radiation therapy,
or following lymphocyte depleting chemotherapy have provided encouraging results
without the side effect of graft versus host disease (GVHD).

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